THERMAL SCIENCE

International Scientific Journal

Thermal Science - Online First

online first only

Nonstationary heat transfer in gels applied to biotehnology

ABSTRACT
Unsteady heat transfer in agarose gels of various concentrations was studied in order to make a breakthrough in the technology of 3D additive bioprinting. Data on the kinetics of the phase transformation was obtained using spectroscopy as a function of temperature during the formation of agarose hydrogel. The dynamics of aging was investigated for gels of different densities. The time dependence of the structural changes were obtained. Particular attention was paid to the changes in the structure of the gel due to the processes of evaporation of the liquid during the gel formation and during long-term storage. Experiments were performed to determine the dynamics of the temperature fields simultaneously with heat flux measurements during the formation of agarose gels from different initial concentrations. A technique based on experimental data for the computations of the thermophysical coefficients of agarose gels was developed.
KEYWORDS
PAPER SUBMITTED: 2017-04-15
PAPER REVISED: 2017-04-22
PAPER ACCEPTED: 2017-04-23
PUBLISHED ONLINE: 2017-05-06
DOI REFERENCE: https://doi.org/10.2298/TSCI170415125P
REFERENCES
  1. Placzek, M. R., et al., Stem Cell Bioprocessing: Fundamentals and Principles, J. R. Soc. Interface, 6 (2009), pp. 209-232
  2. Hölzl, K., et al., Bioink Properties Before, During and After 3D Bioprinting, Biofabrication, 8 (2016), ID 032002
  3. Rodrigues, C. A. V., et al., Stem Cell Cultivation in Bioreactors, Biotechnology Advances, 29 (2011), pp. 815-829
  4. Zaldivar, R. J., et al., Influence of Processing and Orientation Print Effects on the Mechanical and Thermal Behavior of 3D-Printed ULTEM® 9085 Material, Additive Manufacturing, 13 (2017), pp. 71-80
  5. Choi, J., et al., 4D Printing Technology: A Review, 3D Printing and Additive Manufacturing, 2 (2015), 4, pp. 159-167
  6. Marga, F., et al., Toward Engineering Functional Organ Modules by Additive Manufacturing, Biofabrication, 4 ( 2012), ID 02200
  7. Wang, M. Y., et al., The Trend Towards in Vivo Bioprinting, International Journal of Bioprinting, 1 (2015), 1, pp. 15-26
  8. Wang, S., et al., Smart Hydrogels for 3D Bioprinting, International Journal of Bioprinting, 1 (2015), 1, pp. 3-14
  9. Hitchens, A. P., Leikind, M. C., The Introduction of Agar-Agar into Bacteriology, Journal of Bacteriology, 37 (1939), 5, pp. 485-493
  10. Tuson, H. H., et al., Polyacrylamide Hydrogels as Substrates for Studying Bacteria, Chemical Communications, 48 (2012) pp. 1595-1597
  11. Rivest, Ch., et al., Microscale Hydrogels for Medicine and Biology: Synthesis, Characteristics and Applications, Journal of Mehanics of Materials and Structures, 2 (2007), 6, pp. 1103-1119
  12. Weiss, R. G., Terech, P., (Eds.), Molecular Gels: Materials with Self-assembled Fibrillar Networks, Springer Science & Business Media, Dordrecht, Netherlands, 2006
  13. Kajiwara, K., Osada, Yo., (Eds.), Gels Handbook. Four-Volume Set , Elsevier, Amsterdam, 2000
  14. Crompton, T. R., Polymer Reference Book, Rapra Technology Limited, Shropshire, UK, 2006
  15. Amsden, B., Solute Diffusion Within Hydrogels. Mechanisms and Models, Macromolecules, 31 (1998), pp. 8382-8395
  16. Duckworth, M., Yaphe, W., The Structure of Agar. Part I. Fractionation of a Complex Mixture of Polysaccharides, Carbohydrate Research, 16 (1971), pp. 189-97
  17. Rees, D. A., Polysaccharide Shapes and Their Interactions - Some Recent Advances, Pure and Applied Chemistry, 53 (1981), 1, pp. 1-14
  18. Rees, D. A., et al., Correlation of Optical Activity with Polysaccharide Conformation, Nature, 227 (1970) pp. 390-392
  19. Santos, G. A., A Manual for the Processing of Agar from Gracilaria, ASEAN/UNDP/FAO Regional Small-Scale Coastal Fisheries Development Project, Manila, 1990
  20. Pokusaev, B. G., et al., Initiation of Convection Flows in the Wall Granular Layer in the Problem of Boiling of Subcooled Coolant, High Temperature, 54 (2016), 5, pp. 708-715
  21. Zhang, W., et al., Thermal Properties of Wool Fabric Treated by Phosphorus-Doped Silica Sols Through Sol-Gel Method, Thermal science, 18 (2014), 2, pp. 1603-1605
  22. Pokusaev, B. G., et al., Diffusion of Nano-Particles in Gels, Chemical Engineering Tranactions, 47 (2016) pp. 91-96
  23. Arnott, S., Fulmer, W., The Agarose Double Helix and Its Function in Agarose Gel Structure, Journal of Molecular Biology, 90 (1974), pp. 269-284
  24. Berlin, J., et al., Inject Able Hydrogel Based Medical Devices, Bonezone, 9 (2016), www.orthoworld.com/index.php/publications/print_article/221558
  25. Polyanin, A. D., et al., Hydrodynamics, Mass and Heat Transfer in Chemical Engineering, Taylor & Francis, London, 2002
  26. Pokusaev, B. G., et al., Equilibrium Acoustic Velocity in Vapor-Liquid Mixture in Layer of Spherical Particles, Thermal science, 18 (2014), 2, pp.591-602