This paper focuses on the validation and applicability of CFD to simulate and analyze the thermo-hydraulic consequences of a main steam line break. Extensive validation data come from experiments performed using the Rossendorf coolant mixing model facility. For the calculation, the range of 9 to 12 million hexahe¬dral cells was constructed to capture all details in the interrogation domain in the system. The analysis was performed by running a time-dependent calculation, Detailed analyses were made at different cross-sections in the system to evaluate not only the value of the maximum and minimum temperature, but also the loca¬tion and the time at which it occurs during the transient which is considered to be indicator for the quality of mixing in the system. CFD and experimental results were qualitatively compared; mixing in the cold legs with emergency core cooling systems was overestimated. This could be explained by the sensitivity to the bound¬ary conditions. In the downcomer, the experiments displayed higher mixing: by our assumption this related to the dense measurement grid (they were not modelled). The temperature distribution in the core inlet plane agreed with the measurement results. Minor deviations were seen in the quantitative comparisons: the maximum temperature difference was 2ºC.