International Scientific Journal

Thermal Science - Online First

online first only

A linearized non-isothermal general rate model for studying thermal effects in liquid chromatographic columns

A linearized non-isothermal general rate model is formulated and analytically solved to quantify the effects of temperature variations in fixed-bed chromatographic columns. The model contains a set of four coupled partial differential equations (PDEs) accounting for energy transfer resistances, inner and outer particle-pore diffusions, and interfacial mass and axial dispersion. The Laplace transform, the eigenvalue-decomposition technique, and a conventional technique for the solutions of ordinary differential equations (ODEs) are jointly employed for the solution of the model equations. A few numerical test studies are considered to assess the impact of system parameters on the performance of packed-bed adsorption columns. To access the range of applicability and to get the scope of the appropriateness of calculated analytical results, the numerical results are also obtained by applying a high resolution finite volume scheme (HR-FVS). The analytical solutions obtained can be used as an invaluable tool for analyzing, optimizing, and upgrading the non-isothermal liquid chromatographic procedures.
PAPER REVISED: 2020-10-26
PAPER ACCEPTED: 2020-10-27
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