THERMAL SCIENCE

International Scientific Journal

Nadia Kiran

,

Sadia Perveen

,

Seemab Bashir

,

Shamsul Qamar

A LINEARIZED NON-ISOTHERMAL GENERAL RATE MODEL FOR STUDYING THERMAL EFFECTS IN LIQUID CHROMATOGRAPHIC COLUMNS

ABSTRACT
A linearized non-isothermal general rate model is formulated and analytically solved to quantify the effects of temperature variations in fixed-bed chromatographic columns. The model contains a set of four coupled PDE accounting for energy transfer resistances, inner and outer particle-pore diffusions, and interfacial mass and axial dispersion. The Laplace transform, the eigenvalue-decomposition technique, and a conventional technique for the solutions of ODE are jointly employed for the solution of the model equations. A few numerical test studies are considered to assess the impact of system parameters on the performance of packed-bed adsorption columns. To access the range of applicability and to get the scope of the appropriateness of calculated analytical results, the numerical results are also obtained by applying a high resolution finite volume scheme. The analytical solutions obtained can be used as an invaluable tool for analyzing, optimizing, and upgrading the non-isothermal liquid chromatographic procedures.
KEYWORDS
Non-isothermal chromatography, general rate model, linearized isotherm, thermal effects, analytical solutions, numerical solutions, finite volume scheme
PAPER SUBMITTED: 2020-07-29
PAPER REVISED: 2020-10-26
PAPER ACCEPTED: 2020-10-27
PUBLISHED ONLINE: 2020-12-05
DOI REFERENCE: https://doi.org/10.2298/TSCI200729336K
CITATION EXPORT: view in browser or download as text file
THERMAL SCIENCE YEAR 2021, VOLUME 25, ISSUE Issue 5, PAGES [3987 - 4002]
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A linearized non-isothermal general rate model for studying thermal effects in liquid chromatographic columns

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