THERMAL SCIENCE

International Scientific Journal

SILK FIBROIN/POLYETHYLENE GLYCOL NANO-FIBROUS MEMBRANES LOADED WITH CURCUMIN

ABSTRACT
In order to improve the stability, utilization ratio and anti-tumor effect of curcumin drug, a set of curcumin-loaded nano-fiber membranes with drug releasing property were fabricated using silk fibroin (SF) and polyethylene glycol (PEG). Various curcumin-loaded silk firobin nano-fiber membranes (CSFN) with different components and drug loading percentages were prepared using electrospinning technology. The morphology structure, mechanical properties, secondary structure, drug release property in vitro and their interaction effects of the CSFN were examined. The result of in-vitro drug release experiment showed that the curcumin can be released stably up to 350 hours, the drug releasing speed increased with the decrease of the diameter of the fiber. The stability and utilization ratio of curcumin was improved after loading with CSFN membranes. In conclusion, it can be used as a control drug release system alternately in the future.
KEYWORDS
PAPER SUBMITTED: 2016-07-08
PAPER REVISED: 2016-08-05
PAPER ACCEPTED: 2016-08-22
PUBLISHED ONLINE: 2017-09-09
DOI REFERENCE: https://doi.org/10.2298/TSCI160708039L
CITATION EXPORT: view in browser or download as text file
THERMAL SCIENCE YEAR 2017, VOLUME 21, ISSUE 4, PAGES [1587 - 1594]
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© 2017 Society of Thermal Engineers of Serbia. Published by the Vinča Institute of Nuclear Sciences, Belgrade, Serbia. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International licence