The Airbus A380 cabin is selected as the research object to study the smoke and temperature propagation process of upper cabin fires. The results show that during the fire, the overall spread of smoke lasted for 600 s. At z=3.6 m in the upper cabin aisle, the time required for smoke propagation in first class, business, and luxury economy cabins is 89 s, 59 s, and 83 s. At z=3.6 m in the upper cabin seats, the time required for smoke propagation in first class, business, and luxury economy cabins is 89 s, 82 s, and 106 s. The closer the cabin is to the front of the first class cabin, the higher the temperature, while the closer the business cabin is to the fire source, the higher the temperature. In the upper cabin aisle and seats, the temperature in first class, business class, and luxury economy class is higher as it gets closer to the fire source. The ranking of comprehensive danger level from low to high is luxury economy class, first class, and business class.