The impact of heat and mass transfer were analyzed in the present investigation by considering the peristaltic transport of a Jeffery fluid with nanoparticles in a uniform tube. Lubrication theory hypotheses have been considered and expressions have been defined for axial velocity, pressure drop, frictional force, heat and mass transfer effects. The patterns of the stream line and trapped bolus were graphically depicted at the end. It is found that with regard to the modification of various parameters, pressure drop and frictional force exhibit identical behavior. By increasing/decreasing the local temperature Grashof number, Brownian motion parameter and local nanoparticle Grashof number, pressure drop and axial velocity can be regulated.