To improve the energy-saving effect of the ground source heat pump air-conditioning system, an example is investigated, and the annual loads of the building are simulated and analyzed. The thermal energy management operation modelling is conducted. The hydraulic analysis is performed for different modes in each section. Given the same flow and tube type, a larger pipe diameter indicates a smaller hydraulic loss. Compared with the parallel 5-well loop and the parallel 10-well loop, the hydraulic loss of the series 2-well loop is the highest. When the sub-catch is connected to 5 loops, as the number of series wells increases, the tube length gets longer, the flow rate allocated by the loop gets less, and the load increases. Besides, the energy efficiency ratio of the ground source side decreases as the heat rejection load increases. Therefore, by adjusting the pipe diameter, the pipe type, and the depth of the well, the hydraulic loss can be reduced. The energy-saving effect of the loop in the parallel mode is better. Given the limited number of the managed wells, the parallel circuit can be adjusted to the same program. The connection allows the collector to distribute the flow evenly. The energy efficiency ratio of the ground source can be improved by changing the diameter of the horizontal trunk pipe. It is hoped that the hydraulic optimization design of the ground source heat pump air-conditioning system can provide a theoretical basis for the application and promotion of the ground source heat pumps.