Energy system in Serbia, in the whole energy chain, from exploitation of primary energy sources, transformations in electric power plants and district heating plants, energy (electric and heat) transmission and distribution to final users, and up to final energy consumption, is faced with a number of irrational and inefficient behavior and processes. In order to fight with such situation National Energy Efficiency Program, financed by the Ministry of Science and Environmental Protection has been founded in 2001. Basic facts about status of energy sector in Serbia, with special emphasis on the energy efficiency and use of renewable energy sources have been given in the review paper published in the issue No. 2, 2006 of this journal. In present paper new strategy and priorities of the National Energy Efficiency Program for the future period from 2006 to 2008, and beyond, is presented. This strategy and priorities are mainly based on the same concept and principles as previous, but new reality and new and more simulative economic and financial environment in energy sector made by the Energy low (accepted by Parliament in 2004) and Strategy of Development of Energy Sector in Republic Serbia up to 2015 (accepted by the Parliament in May 2005), have been taken into account. Also, responsibilities that are formulated in the Energy Community Treaty signed by the South-East European countries, and also coming from documents and directives of the European Community and Kyoto Protocol are included in new strategy. Once again necessity of legislative framework and influence of regulations and standards, as well as of the governmental support, has been pointed out if increased energy efficiency and increased use of renewable energy sources are expected. .