Thermo-hydrodynamic models have been caught much attention in textile engineering, environmental science, micromechanics, and other fields. This issue solicits some thermo-hydrodynamic models for vapor-liquid two-phase flows, precipitation forecast, nozzle optimization, supercritical CO2, microfluid, Brownian coagulation, skin thermal property, aerodynamic thermal environment, solar seasonal storage, lotus effect, unsteady cavitation flow, air permeability of nanofiber membrane and others. This issue also publishes some fractional models, lattice models, and spatio-temporal dynamic models for dis-continuous problems. All these models are solved either numerically or analytically and verified experimentally. Numerical methods include the genetic algorithm, the Monte-Carlo method and others, the analytical methods are the homotopy perturbation method, the fractional power series and others.