TY - JOUR
TI - A critical review on heat and mass transfer modelling of viral infection and virion evolution: The case of SARS-CoV2
AU - Trancossi Michele
AU - Pascoa Jose
AU - Sharma Shivesh
JN - Thermal Science
PY - 2021
VL - 25
IS - 4
SP - 2831
EP - 2843
PT - Article
AB - Is it possible to characterize the SARS-CoV-2 viral infection by analyzing  the viral hijacking of cellular metabolism for its reproduction and  multiplication? Gibbs free energy appears to be the critical factor of  successful virus infection. A virus always has a more negative Gibbs free  energy of growth than its host. Hence, the synthesis of viral components is  thermodynamically favourable. On the other side, it could be essential to  better thermodynamically understand how S1 and S2 spike protein interacts  with the ACE2 receptors and the cell membrane more efficiently than the  usual nutrients, which are intercepted. Gibbs energy gives a static model,  which does not include the time arrow of viral evolution. A better  comprehension of this evolutional path could require an accurate analysis of  entropy generation or exergy disruption of binding, replication, and  multiplication.