TY - JOUR
TI - Silk fibroin/polyethylene glycol nano-fibrous membranes loaded with curcumin
AU - Liu Qing
AU - Xie Maobin
AU - Li Gang
AU - Zheng Zhaozhu
AU - Xie Ruijuan
AU - Liu Lei
AU - Xu Siyue
AU - Wang Rong
AU - Wu Ting
AU - Zhao Zeyu
AU - Zhou Shufa
AU - Wang Xiaoqin
JN - Thermal Science
PY - 2017
VL - 21
IS - 4
SP - 1587
EP - 1594
PT - Article
AB - In order to improve the stability, utilization ratio and anti-tumor effect of  curcumin drug, a set of curcumin-loaded nano-fiber membranes with drug  releasing property were fabricated using silk fibroin (SF) and polyethylene  glycol (PEG). Various curcumin-loaded silk firobin nano-fiber membranes  (CSFN) with different components and drug loading percentages were prepared  using electrospinning technology. The morphology structure, mechanical  properties, secondary structure, drug release property in vitro and their  interaction effects of the CSFN were examined. The result of in-vitro drug  release experiment showed that the curcumin can be released stably up to 350  hours, the drug releasing speed increased with the decrease of the diameter  of the fiber. The stability and utilization ratio of curcumin was improved  after loading with CSFN membranes. In conclusion, it can be used as a control  drug release system alternately in the future.